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AssigneeBoston Scientific Scimed, Inc.
InventorsJ. Thomas Ippoliti, Scott Schewe, Michele Zoromski, Robert W. Warner, Liliana Atanasoska, Jan Weber
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According to an aspect of the present invention, implantable or insertable blood-contacting devices are provided, which contain one or more release regions that release nitric oxide and one or more anti-restenotic agents. The release region contains one or more polymeric components. The release region also optionally contains one or more inorganic components. Nitric oxide producing groups may be attached to the polymeric component(s), to the optional inorganic component(s), or both. The one or more anti-restenotic agents may be admixed with the polymeric and optional inorganic components, attached to the polymeric component(s), attached to the optional inorganic component(s), or a combination thereof.
An implantable or insertable blood-contacting medical device comprising a release region that releases nitric oxide and an anti-restenotic agent, said release region comprising a polymeric component and an optional inorganic component, said release region comprising nitric oxide releasing groups that are attached to the polymeric component, to the optional inorganic component, or both, and said release region comprising an anti-restenotic agent, which is admixed with the polymeric and optional inorganic components, attached to the polymeric component, attached to the optional inorganic component, or a combination thereof.
Dependencies are inferred from the claim text.