Eliciting improved immune responses
AssigneeThe Binding Site Limited
InventorsArthur Randall BRADWELL, Graham Peter MEAD
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Abstract
An improved immune response is achieved in an animal by administering, for example injecting, a cocktail of peptides that are similar to, but different from, a target peptide against which it is desired to create antibodies. The similar peptides preferably have the same peptide sequence as the target peptide, but with one or more amino acids substituted for a chance-selected, random, amino acid from a group of allowable amino acids. The peptides may be present on a multi-branch peptide.
Claims16
A composition for eliciting an immune response against a target protein, the composition comprising a plurality of synthesised peptide ingredients comprising a first peptide substantially homologous to a first portion of the target protein except for an amino acid in at least one amino acid position in the first peptide being randomly-selected from a pool consisting of naturally occurring amino acids and/or amino acid analogs.
A composition for eliciting an immune response against a target protein, the composition comprising a plurality of synthesised peptide ingredients, each ingredient being adapted for eliciting an immune response against the target protein, by the steps of:
- i) synthesising a first peptide substantially homologous to a portion of the target protein, wherein in at least one amino acid position an amino acid is taken at random from a pool consisting of naturally occurring amino acids and amino acid analogs;
- ii) obtaining a plurality of the first peptide, wherein in each of the plurality of the first peptide the amino acid in the at least one amino acid position is taken at random from the pool;
- and
- iii) providing the plurality of the first peptide in a suitable composition.
Dependencies are inferred from the claim text.