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OwnerCarolyn R. BERTOZZI, Spencer J. WILLIAMS +1inventors
InventorsCarolyn R. BERTOZZI, Spencer J. WILLIAMS, Joseph D. MOUGOUS
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Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting growth and/or virulence of a pathogenic mycobacterium, and methods of treating disease conditions associated with a pathogenic mycobacterium, particularly by administering an inhibitor of a mycobacterial sulfation pathway protein. The present invention further provides genetically modified mycobacteria having a defect in a sulfation pathway enzyme gene; and immunogenic compositions that include such genetically modified mycobacteria.
A genetically modified mycobacterium, wherein said genetically modified mycobacterium comprises a functionally disabled sulfation pathway gene, such that said sulfation pathway gene does not direct expression of a functional sulfation pathway polypeptide, wherein said genetically modified mycobacterium is avirulent.
A genetically modified mycobacterium, wherein said genetically modified mycobacterium comprises a modified sulfation pathway gene, such that said sulfation pathway gene does not direct expression of a sulfation pathway polypeptide, wherein said genetically modified mycobacterium is avirulent.
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