P. gingivalis antigenic composition
AssigneesCSL Limited, The University of Melbourne
InventorsEric C. Reynolds, Nada Slakeski, Chao Guang Chen, Ian George Barr
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Abstract
The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.
Claims11
1-15. (canceled)
An antigenic composition, the composition comprising at least one recombinant protein having a molecular weight of less than or equal to 44 kDa as estimated by SDS-PAGE, wherein the recombinant protein comprises at least one epitope, the epitope being reactive with an antibody wherein the antibody is reactive with a polypeptide having the sequence selected from the group consisting of SEQ. ID. NO. 5 and SEQ. ID. NO. 6.
20-23. (canceled)
A method of preventing or reducing the incidence or severity of P. gingivalis infection in a subject, the method comprising administering to the subject an antigenic composition, wherein the composition comprises at least one recombinant protein having a molecular weight of less than or equal to 44 kDa as estimated by SDS-PAGE, wherein the recombinant protein comprises at least one epitope, the epitope being reactive with an antibody wherein the antibody is reactive with a polypeptide having the sequence selected from the group consisting of SEQ. ID. NO. 5 and SEQ. ID. NO. 6.
28-29. (canceled)
Dependencies are inferred from the claim text.