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US 2008/0175857 A1Published application
Streptococcus pneumoniae proteins and nucleic acid molecules
AssigneeSanofi Pasteur Limited
InventorsChristophe Francois Guy Gilbert, Philip Michael Hansbro
Life of this patent
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Abstract
Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.
Claims29
1-20. (canceled)
An isolated Streptococcus pneumoniae polypeptide comprising:
- (a) SEQ ID NO:
- 1-167, 184-195;
- or
- (b) a homologue, derivative, or fragment of a sequence of (a) that retains the antigenicity or immunogenicity of the sequence from which it is derived.
1 more element
An isolated Streptococcus pneumoniae nucleic acid molecule comprising:
- (a) SEQ ID NO:
- 168-183, 196-363, or an RNA equivalent thereof;
- (b) a sequence that is complementary to a sequence of (a);
- (c) a sequence that codes for the same polypeptide as a sequence of (a) or (b);
- (d) a sequence that shares at least 50% sequence similarity with a sequence of (a), (b), or (c);
- or
- (e) a sequence that codes for a homologue, derivative, or fragment of the polypeptide encoded by a sequence of (a), (b), (c), or (d);
- and
- wherein the polypeptide coded for by the sequence of (b), (c), (d), or (e) retains the antigenicity or immunogenicity of the polypeptide encoded by the sequence from which it is derived.
6 more elements
An isolated antibody or fragment thereof that binds to a Streptococcus pneumoniae polypeptide comprising:
- (a) SEQ ID NO:
- 1-167, 184-195;
- or
- (b) a homologue, derivative, or fragment of a sequence of (a) that retains the antigenicity of the polypeptide encoded by the sequence from which it is derived.
1 more element
Dependencies are inferred from the claim text.