Peptide useful in immunomodulation
AssigneesCureTech Ltd., Mor Research Applications Ltd.
InventorsBritta Hardy, Annat Raiter, Leah Klapper
Life of this patent
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Abstract
The present invention provides peptides and polynucleotides, and their use for immunomodulation, immunotherapy and vaccine particularly for anti-cancer therapy, and for diagnosis purposes. The immunomodulatory effect includes induction of proliferation and activation of peripheral blood lymphocytes and induction of an anti-tumor effect upon administration of peptides of the invention to subjects suffering from cancer.
Claims13
An isolated peptide comprising at least one epitope that is recognized by and binds to a BAT monoclonal antibody, said peptide selected from the group consisting of:
- (a) a peptide having the sequence of any one of SEQ ID NOs:
- 3 through 5
- (b) a peptide having at least 90% identity with a peptide of (a);
- and
- (c) a combination of peptides according to (a) or (b).
A pharmaceutical composition comprising as an active ingredient at least one isolated peptide comprising at least one epitope that is recognized by and binds to a BAT monoclonal antibody, said peptide selected from the group consisting of:
- (a) a peptide having the sequence of any one of SEQ ID NOs:
- 3 through 5;
- (b) a peptide having at least 80% identity with a peptide of (a);
- (c) a combination of peptides according to (a) or (b);
- and
- a pharmaceutically acceptable carrier, excipient or diluent selected from the group consisting of:
- glucose, mannitol, inositol, sucrose, lactose, fructose, starch, cornstarch, microcrystalline cellulose, hydroxypropylcellulose, hydroxypropyl-methylcellulose, or polyvinylpyrrolidone.
Dependencies are inferred from the claim text.