Methods for treating conditions associated with the accumulation of excess extracellular matrix
AssigneeUniversity of Utah Research Foundation
InventorsNancy A. Noble, Wayne A. Border
Life of this patent
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Abstract
The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGFβ, or using agents that inhibit TGFβ in combination with agents that degrade excess accumulated extracellular matrix, or at least one agent that degrades excess accumulated extracellular matrix. The compositions and methods of the invention are used to treat conditions such as fibrotic diseases and scarring that result from excess accumulation of extracellular matrix, impairing tissue or organ function or skin appearance in a subject.
Claims20
A method for reducing excess accumulation of extracellular matrix associated with TGFβ overproduction and/or activity, in a tissue and/or organ, or at a dermal wound site, by administering a combination of agents that inhibit TGFβ, in an amount sufficient to inhibit TGFβ overproduction and/or activity, the administration of said combination of agents resulting in greater reduction in extracellular matrix, than when each agent is administered separately, whereby the accumulation of extracellular matrix in said tissue and/or organ or wound site is reduced from the level existing at the time of administration of the agents.
A method for reducing excess accumulation of extracellular matrix associated with TGFβ overproduction and/or activity, in a tissue and/or organ, or at a dermal wound site, by degrading excess accumulated extracellular matrix, whereby the accumulation of extracellular matrix in said tissue and/or organ or wound site is reduced from the level existing at the time of administration of the agent.
20-28. (canceled)
Dependencies are inferred from the claim text.