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US 2008/0175836 A1Published application
Immunogenic composition based on conditionally live virion and method for producing the same
OwnerNelson M. Karpinventor
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OwnerNelson M. Karpinventor
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A conditionally live virion and method for making the same whereby the viral DNA or RNA is modified so that the virion is incapable of replication unless a protein supplement is added to the expression system. The expression system is either a traditional cell culture or cell free expression system suitable for self assembly of viral particles. Both expression systems require the addition of viral proteins either for replication or assembly of the replication incompetent virion. The conditionally live viron is then used for creating a vaccine with three fold immunogenic properties that are elicited by 1) the whole intact replication incompetent virus; 2) the conditionally live virion temporally resuscitated by addition of protein supplements; and 3) the protein supplement itself acting as a subunit vaccine.
A method for the production of at least one conditionally live virion, comprising the steps of:
An immunogenic composition comprising:
A method for the production of a viral vaccine, comprising the steps of:
An immunogenic composition comprising:
Dependencies are inferred from the claim text.