Use of Cytokines and Mitogens to Inhibit Pathological Immune Responses
AssigneeUniversity of Southern California
InventorDavid A. Horwitz
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Abstract
The invention is generally related to methods of treating autoimmune diseases, including both antibody-mediated and cell-mediated disorders.
Claims22
An isolated population of cells comprising at least 50% immunosuppressive regulatory T cells, wherein said immunosuppressive regulatory T cells are CD4+ CD25+.
A method of identifying immunosuppressive regulatory T cells in a sample comprising:
- screening T cells in said sample to detect CD4+ CD25+ T cells;
- and
- identifying said detected CD4+ CD25+ T cells as immunosuppressive regulatory T-cells.
A pharmaceutical composition for suppressing a pathological immune response in a subject, wherein said pharmaceutical composition comprises isolated immunosuppressive CD4+ CD25+ regulatory T cells.
The pharmaceutical composition according to claim 20, wherein said antigen is selected from:
- an alloantigen and an autoantigen.
Dependencies are inferred from the claim text.