Neuronal regeneration material screening method by ex vivo model
AssigneeSeoul National University Industry Foundation
InventorsMi-Sook Chang, Jung Sun Cho
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Abstract
The present invention relates to a neuronal regeneration material screening method using ex vivo models, more precisely a neuronal regeneration material screening method using an organotypic spinal cord slice culture. The neuronal regeneration material screening method using spinal cord slices of living bodies of the present invention can be effectively applied for the development of a novel therapeutics for neurodegenerative diseases, such as spinal cord injury.
Claims12
A method for screening a neuronal regeneration material comprising the following steps:
- 1) Culturing tissue slices obtained from the spinal cord;
- 2) Damaging the tissue slices in course of the culture of step 1) by treating with a toxic compound;
- 3) Treating neuronal regeneration material candidates to the damaged tissue slices;
- and
- 4) Selecting neuronal regeneration material candidates that exhibit significant neuronal regeneration effect, compared with the negative control untreated with such candidates.
A method for inducing remyelination of the demyelinated axons in the spinal cord, which includes the step of transplanting bone marrow-derived mesenchymal stem cells into the damaged spinal cord of a subject.
A cell composition for remyelination of the demyelinated axons in the spinal cord, which comprises bone marrow-derived mesenchymal stem cells.
Dependencies are inferred from the claim text.