Quinoline derivatives for modulating dna methylation

A compound of formula (I), or a physiologically acceptable salt or a phosphate prodrug, or a carboxylic acid or aminoacid ester prodrug thereof,

• wherein G1, G2, G3, and G4 are each independently C, N, or N+ (where an R6-R9 is attached to N);
• G5 and G6 are each independently CH or N;
• G7 and G8 are each independently CH, C (where an R2 is attached to C), N, or N+ (where an R2 is attached to N),
• D1 and D2 are each separately CH, C (where R3 attached to C), N, or N+ (where an R3 is attached to N).
• R6, R7, R8, and R9 are each separately H, halogen, CF3, OCF3, CN, CONHR4, CONR4R5, SO2Me, SO2NHR4, SO2NR4R5, NHCOR4, NHR4, NR4R5, OR4, NO2, or CH2R4, wherein R4 and R5 are each independently H, lower C1-C6 alkyl or cycloalkyl optionally substituted with amino, hydroxyl or methoxy groups, or with one or more oxygen or nitrogen atoms as part of the cycloalkyl structure which may represent morpholine, pyrrolidine, piperidine, imidazole or 4-methylpiperazine, or may be substitution of a —CH═ ring carbon by —N═,
• R2 and R3 are each independently H, NHR4, NR4R5, OR4, NO2 or CH2R4, wherein R4 and R5 are defined as above,
• X may be H or C1-C6 alkyl optionally substituted with amino, hydroxyl or methoxy groups, or with one or more oxygen or nitrogen atoms as part of a cycloalkyl structure which may represent azetidine, pyrrolidine, piperidine, piperazine, or morpholine;
• Y may be CONR4, NR4CO, O, S(O)n [n=0 to 2], (CH2)k [k=1 to 6], —CH═CH—, NR4, or a direct link between the two aromatic rings (i.e., a C—C bond between the two aromatic rings), wherein R4 and R5 are defined as above;
• o, m and p represent positions of attachment of the moiety Z;
• Z may be one of the groups Q1-Q43 represented in formula (II);
• wherein A is O or NR4, wherein R4 is defined as above,
• G9-G13 are each independently C, N, or N+ (where an R10-R13 is attached to N);
• but at least three of G9-G13 are C;
• and
• R10, R11, R12, R13, and R14 are each separately H, halogen, alkyl, CF3, OCF3, CN, CONHR4, CONR4R5, SO2Me, SO2NHR4, SO2NR4R5, NHCOR4, NHR4, NR4R5, OR4, NO2 or CH2R4, wherein R4 and R5 are as defined above.