Novel derivatives of amino acids for treatment of obesity and related disorders

A compound of the formula (I):

• its derivatives, stereoisomers, pharmaceutically acceptable salts and pharmaceutical compositions, wherein,
• ______ represents a bond or no bond;
• A is selected from the group consisting of substituted and unsubstituted 5 to 18-membered aryl and heterocyclyl;
• B represents a ring system selected from the group consisting of substituted and unsubstituted 5 to 18-membered aryl, 5 to 6 membered saturated and unsaturated heterocyclyl having 1-4 hetero atoms selected from N, O or S;
• R1 represents —OR11 or NR11R12;
• R2 and R3 may be same or different and independently represent H, COR13, substituted or unsubstituted groups selected from alkyl, alkenyl, aryl, heteroaryl, alkylsulfonyl, alkylsulfinyl, arylsulfonyl, arylsulfinyl, alkylthio, arylthio or heterocyclyl;
• R4 represents hydrogen, substituted or unsubstituted groups selected from the group consisting of alkyl, aryl, heteroaryl, heterocyclyl and araalkyl;
• R5 represents H, halogen, nitro, cyano, formyl, amino, substituted or unsubstituted groups selected from the group consisting of alkyl, alkenyl, haloalkyl, alkoxy, aryl, heteroaryl, heterocyclyl, monoalkylamino, dialkylamino, alkanoyl and carboxylic acids and its derivatives;
• R7, R8, and R9 may be same or different and represent hydrogen, nitro, nitrile, hydroxy, formyl, azido, halo, or substituted or unsubstituted groups selected from the group consisting of alkyl, alkoxy, acyl, cycloalkyl, haloalkyl, amino, hydrazine, monoalkylamino, dialkylamino, acylamino, alkylsulfonyl, alkylsulfinyl, arylsulfonyl, arylsulfinyl, alkylthio, arylthio, alkoxycarbonyl, aryloxycarbonyl, alkoxyalkyl, sulfamoyl and carboxylic acid and its derivatives;
• R10 represents hydrogen, substituted or unsubstituted groups selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, heteroaryl and a counter ion;
• R11 and R12 may be same or different and independently represent H, substituted or unsubstituted groups selected from the group consisting of alkyl, alkenyl and aryl or R11 and R12 together with nitrogen may represent substituted or unsubstituted mono or bicyclic saturated or unsaturated ring system which may contain one or more heteroatoms selected from O, S or N;
• R13 represents H, substituted or unsubstituted groups selected from the group consisting of alkyl, aryl, alkenyloxy, aryloxy, alkoxy and aralkoxy;
• Z represents O, S or NR14, R14 represents hydrogen or alkyl;
• when Z represents O or S, R6 represents hydrogen or substituted or unsubstituted groups selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heteroaryl, heteroaralkyl and heterocyclyl;
• when Z represents NR14, R6 represents H, hydroxy, protected hydroxyl group, alkyloxy, aryloxy, amino, substituted or unsubstituted groups selected from the group consisting of alkyl, haloalkyl, alkenyl, monoalkylamino, dialkylamino, aryl, aralkyl, cycloalkyl, heteroaryl, heteroaralkyl and heterocyclyl;
• R14 represents hydrogen or alkyl;
• Y represents O, S or NR14;
• m is an integer from 0 to 8;
• n is an integer from 0 to 4;
• X represents a bond, O, S, SO or SO2.