Integrin targeted imaging agents
AssigneesBarnes-Jewish Hospital, Bristol-Myers Squibb Medical Imaging, Inc.
InventorsGregory M. Lanza, Samuel A. Wickline, Tom Harris
Life of this patent
Estimating the term…
Abstract
Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for αvβ3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
Claims13
A composition comprising an emulsion of nanoparticles, wherein said nanoparticles consist of liquid perfluorocarbon cores coated with lipid/surfactant, and
- wherein said nanoparticles are coupled to a ligand specific for αvβ3, which comprises the formula
- and wherein the coupling of said nanoparticles to the ligand is through a covalent linkage, through a spacer, to a component of the lipid/surfactant coating, and
- wherein said nanoparticles incorporate at least one imaging agent.
The composition of claim 10, wherein said biologically active agent is a hormone or pharmaceutical.
Dependencies are inferred from the claim text.