A method for operating a hybrid medical imaging unit including a first imaging device of relatively high spatial resolution and a second nuclear medicine imaging device of relatively high sensitivity that respectively acquire imaging measurement signals from a common examination volume, the method comprising:
- using, during a current measurement signal acquisition of the second imaging device, the continuously acquired measurement signals to determine a region in the examination volume in which a region referred measurement signal acquisition is subsequently performed via the first examination device, using a region referred measurement protocol.