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US 2008/0173553 A1Published application
Detection of analytes using reorganization energy
AssigneeClinical Micro Sensors, Inc.
InventorThomas J. Meade
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Abstract
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
Claims22
A method of detecting a target analyte in a test sample comprising
- a) adding a target analyte to an electrode comprising
- i) a solvent accessible transition metal complex comprising a metal selected from the group consisting of manganese, technetium, rhenium, iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium, platinum, copper, silver and gold;
- and
- ii) a binding ligand that will bind said target analyte;
- such that upon binding of said target analyte to said binding ligand, a solvent inhibited transition metal complex is formed;
- and
- b) measuring a change in E0 of said transition metal complex.
4 more elements
Dependencies are inferred from the claim text.