Gated Amperometry
AssigneeBayer Healthcare LLC, Diabetes Care Division
InventorsHuan-Ping Wu, Christine D. Nelson, Greg P. Beer
Life of this patent
Estimating the term…
Abstract
A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated amperometric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed gated amperometric pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, under-fill, temperature changes in the sample, and a single set of calibration constants.
Claims26
A method for determining the concentration of an analyte in a sample, comprising:
- applying an input signal to the sample, the input signal comprising at least 3 duty cycles within 180 seconds and each duty cycle comprising an excitation and relaxation;
- measuring an output signal responsive to a measurable species;
- and
- determining the concentration of the analyte in the sample in response to the measured output signal.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
19-23. (canceled)
A handheld measuring device, for determining the concentration of an analyte in a sample, where
- the device is adapted to receive a sensor strip and the device comprises:
- contacts;
- at least one display;
- and
- electronic circuitry establishing electrical communication between the contacts and the display, the circuitry comprising:
- an electric charger and a processor in electrical communication, the processor in electrical communication with a computer readable storage medium comprising computer readable software code, which when executed by the processor, causes the charger to implement an input signal comprising at least 3 duty cycles within 180 seconds between the contacts, each duty cycle comprising an excitation and a relaxation.
A method of reducing the bias attributable to mediator background in a determined concentration of an analyte in a sample comprising:
- applying an input signal to the sample, the input signal comprising at least 3 duty cycles within 180 seconds.
A method of signaling a user to add additional sample to a sensor strip, comprising:
- determining if the sensor strip is under-filled by determining a decay constant from currents recorded during at least two excitations of an input signal including at least 3 duty cycles within 180 seconds;
- and
- signaling the user to add additional sample to the sensor strip if the strip is under-filled.
A method of determining the temperature of a sample contained by a sensor strip, comprising:
- determining a decay constant from currents recorded during at least two excitations of an input signal including at least 3 duty cycles within 180 seconds;
- and
- correlating the decay constant with a temperature value.
A method of determining the duration of an input signal including at least 3 duty cycles within 180 seconds, for determining the concentration of an analyte in a sample comprising:
- determining a plurality of calibration points determined from currents recorded during the at least 3 duty cycles;
- and
- determining the duration of the input signal in response to the determined concentration of the analyte in the sample.
Dependencies are inferred from the claim text.