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AssigneeThe Regents of the University of California
InventorsJay D. Keasling, James Kirby, Eric M. Paradise
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The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.
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A eukaryotic host cell comprising one or more heterologous nucleic acids that are integrated into the host cell's chromosome, wherein the chromosomally integrated heterologous nucleic acids alter the level of activity in the host cell of
A eukaryotic host cell comprising one or more heterologous nucleic acids that are integrated into the host cell's chromosome wherein the chromosomally integrated heterologous nucleic acids encode:
A Saccharomyces cerevisiae cell comprising one or more heterologous nucleic acids that are integrated into the cell's chromosome wherein the chromosomally integrated heterologous nucleic acids encode:
Dependencies are inferred from the claim text.