System and method of generating an image of a contrast agent injected into an imaged subject

An imaging system operable to generate an output image of a contrast agent injected into an imaged subject, comprising:

• a energy source in communication with a detector, the detector operable to generate a plurality of radiological images of the imaged subject injected with the contrast agent;
• a display;
• and
• a computer connected in communication the display and to receive the acquired plurality of images from the detector, the computer including a memory in communication with a processor, the memory including a plurality of programmable instructions for execution by the processor, the plurality of programmable instructions including:
• acquiring at least one image of the contrast agent in the imaged subject with a spectra of energy from the energy source;
• detecting a plurality of grayscale values of pixel data of the contrast agent in the at least one image;
• calculating a predicted thickness of the contrast agent relative to the plurality of grayscale values of pixel data of the contrast agent detected in the at least one image;
• and
• generating an output image comprising an illustration of the predicted thickness of the contrast agent for illustration on the display.