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US 2008/0167480 A1Published application
Processes for preparing pyrroles
OwnerMichael Wallaceinventor
Life of this patent
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Abstract
The present invention relates to an improved synthesis of pyrrole capping group precursors.
Claims29
A process for preparing a compound of formula I-a:
- comprising:
- combining an aqueous solution of the compound of formula IV-a:
- wherein R3 is C1-12 aliphatic, C3-12 alkyl-cycloaliphatic, C3-12 alkyl-aryl, C3-12 alkyl-heteroaryl, or C3-12 alkyl-cycloaliphatic;
- with a compound of formula V-a
- wherein R1 and R2 are each independently C1-6 aliphatic;
- in the presence of zinc, water, and optionally an additional suitable solvent to form a compound of formula VI
3 more elements
A process for preparing a compound of formula VI-a:
- comprising, combining an aqueous solution of compound of formula IV-a:
- wherein R3 is C1-12 aliphatic, C3-12 alkyl-cycloaliphatic, C3-12 alkyl-aryl, C3-12 alkyl-heteroaryl, or C3-12 alkyl-cycloaliphatic;
- with a compound of formula V-a
- wherein R1 and R2 are each independently C1-6 aliphatic in the presence of zinc and a suitable solvent to form the compound of formula VI.
1 more element
A process for preparing a compound of formula I-a:
- comprising,
- D) combining an aqueous solution of the compound of formula IV-a:
- wherein R3 is C1-12 aliphatic, C3-12 alkyl-cycloaliphatic, C3-12 alkyl-aryl, C3-12 alkyl-heteroaryl, or C3-12 alkyl-cycloaliphatic;
- with a compound of formula V-a
- wherein R1 and R2 are each independently C1-6 aliphatic;
- in the presence of zinc and a solvent comprising of water and optionally another suitable solvent to form the compound of formula VI:
- E) Acylating the compound of formula VI with a suitable acylating agent to form the compound of formula VII:
- F) Hydrolyzing the compound of formula VII under suitable hydrolysis conditions to form the compound of formula I:
5 more elements
Dependencies are inferred from the claim text.