Novel polymorphic forms of carvedilol dihydrogen phosphate and process for preparing the same
AssigneeMatrix Laboratories Limited
InventorsRamakoteswara Rao JETTI, Asha Rani GORANTLA, Om Dutt TYAGI
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Abstract
The present invention provides novel crystalline polymorphic forms and amorphous form of carvedilol dihydrogen phosphate characterized by different solid state techniques. The novel processes for their preparation are also disclosed.
Claims74
A carvedilol dihydrogen phosphate Form A.
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A crystalline carvedilol dihydrogen phosphate Form B.
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A crystalline carvedilol dihydrogen phosphate Form C.
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A crystalline carvedilol dihydrogen phosphate Form D.
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A crystalline carvedilol dihydrogen phosphate Form E.
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An amorphous carvedilol dihydrogen phosphate Form F.
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A process for preparing crystalline carvedilol dihydrogen phosphate hemihydrate, the process comprises the heating of carvedilol dihydrogen phosphate.
A process for preparing crystalline carvedilol dihydrogen phosphate hemihydrates, the process comprising:
- (a) contacting the carvedilol dihydrogen phosphate in a solvent;
- (b) isolating the solid obtained and dried.
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A process for preparing carvedilol dihydrogen phosphate hemihydrate, the process comprising:
- (a) contacting carvedilol free base in acetonitrile;
- (b) adding 85% phosphoric acid solution in acetonitrile;
- (c) heating the solution;
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- (d) recovering the crystalline carvedilol dihydrogen phosphate hemihydrate.
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Dependencies are inferred from the claim text.