Back to results
US 2008/0167475 A1Published application
Intermediates of 2-substituted carbapenem derivatives and process for production thereof
AssigneeMeiji Seika Kaisha, Ltd.
InventorsToshiro Sasaki, Takashi Ando, Yasuo Yamamoto, Takahiro Imai, Dai Kubota, Katsuhiko Noguchi, Nobuyuki Hori, Eiki Shitara, Kunio Atsumi, Shohei Yasuda
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.
Claims5
1-37. (canceled)
A compound of formula (14):
- wherein X represents a halogen atom.
A process for producing a compound of formula (14), comprising steps (a) and (b):
- wherein X represents a halogen atom,
- (a) reacting a compound of formula (15) with a halogenating agent to give a compound of formula (16) which, optionally after the removal of a protective group, undergoes formylation of amino to give a compound of formula (17):
- wherein
- R8 represents a hydrogen atom, or a protective group of amino and,
- X represents a halogen atom, and
- (b) reacting the compound of formula (17) with a dehydrating agent for cyclization to give a compound of formula (14).
3 more elements
Dependencies are inferred from the claim text.