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US 2008/0167472 A1Published application
Tunable phenylacetylene hosts
AssigneesState of Oregon acting by and through the state, Board of Higher Education on behalf of the University of Oregon.
InventorsMichael M. Haley, Darren W. Johnson, Orion B. Berryman, Charles A. Johnson, Calden N. Stimpson
Life of this patent
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Abstract
Disclosed herein is a class of tunable phenylacetylene compounds as well as compositions and methods for their use as host compounds for ligand binding. In certain examples the hosts report binding events by exhibiting altered spectroscopic properties, such as different fluorescent emission spectra.
Claims31
A compound or salt thereof comprising the formula
- wherein Y represents an optionally substituted aromatic group;
- n is 1 or 2;
- R is H or lower alkyl;
- R1 is H, lower alkyl or aralkyl;
- R2 is selected from H, acyl, aralkyl, phosphonyl, —SO2R3;
- —(R4)C(O)R5;
- —N(R6)C(O)OR and —N(R8)C(O)NR9R10;
- R3;
- R4;
- R5;
- R6;
- R7;
- R8 R9 and R10 independently are selected from H, lower alkyl, aralkyl and aryl.
10 more elements
A method for preparing a host compound, comprising providing a compound of the formula
- and converting it to a compound of the formula
Dependencies are inferred from the claim text.