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US 2008/0167468 A1Published application
Silacycle compounds and methods of use thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJames Lincoln Leighton, Richard Berger, Seiji Shirakawa, Gregory T. Notte
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Abstract
The present invention relates to a diastereomeric mixture of Silacycle Compounds and methods for using the diastereomeric mixture of Silacycle Compounds for stereoselective synthesis.
Claims86
A diastereomeric mixture of:
- (A) an optically active compound having the formula:
- wherein
- R8 is —C1-C6 alkyl, -phenyl, -benzyl, —O—C1-C10 alkyl, —O—(C1-C6 alkylene)-aryl, or —O-aryl;
- R9 is —H, —C1-C6 alkyl, -allyl, -phenyl, or -benzyl;
- R10 is —H, —C1-C6 alkyl, -allyl, -phenyl, or -benzyl, or R10 and R11 are taken together to form:
- R11 is —H, —C1-C6 alkyl, -allyl, -phenyl, or -benzyl, or R11 and R12 are taken together to form —(CH2)3—;
- and
- R12 is —H, —C1-C6 alkyl, or -phenyl;
- and (B) an optically active compound having the formula:
- wherein
- R8, R9, R10, R11, and R12 of the optically active compound of formula (IIIA) and of the optically active compound of formula (IIIB) are the same.
8 more elements
Dependencies are inferred from the claim text.