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US 2008/0167463 A1Published application
Process for Preparation of Gemcitabine Hydrochloride
AssigneeArch Pharmalabs Limited
InventorsAshish Ujagare, D. Kockrekar, Matthew Uzagare
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Abstract
A process for isolating β-anomer enriched Gemcitabine hydrochloride by converting Gemcitabine base into Gemcitabine hydrochloride followed by its purification using solvents from the series of water soluble ethers like 1,4-dioxane or Monoglyme.
Claims23
A process of isolating β-anomer enriched Gemcitabine hydrochloride from the mixture of α & β anomers of Gemcitabine base the steps comprising of
- a) adding water soluble ether to Gemcitabine base
- b) heating the mixture to dissolve the base (oil) and adding thereto hydrochloric acid;
- c) cooling the mixture and
- d) isolating the precipitated β-anomer enriched Gemcitabine hydrochloride.
1 more element
A process for purification of 8-anomer enriched Gemcitabine hydrochloride comprising the steps of
- a) dissolving β-anomer enriched Gemcitabine hydrochloride in water by heating the contents;
- b) addition of a water soluble ether and cooling the mixture;
- and
- c) crystallizing the purified β-anomer enriched Gemcitabine hydrochloride.
1 more element
Dependencies are inferred from the claim text.