Antibodies to tumor associated proteins
AssigneeAgensys, Inc.
InventorsArthur B. Raitano, Karen Jane Meyrick Morrison, Wangmao Ge, Pia M. Challita-Eid, Aya Jakobovits
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Abstract
A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
Claims18
1-22. (canceled)
Antibodies or antigen binding fragments thereof specifically immunoreactive with a 24P4C12 protein that has the amino acid sequence of SEQ ID NO:
- 3 or is an allelic variant thereof that has an amino acid sequence at least 90% identical to SEQ ID NO:
- 3 or has the amino acid sequence shown in SEQ ID NO:
- 15.
Dependencies are inferred from the claim text.