Receptor Function Regulation Agent
AssigneeTakeda Pharmaceutical Company Limited
InventorsKohji Fukatsu, Ryo Fujii, Makoto Kobayashi, Jinichi Yonemori, Toshio Tanaka
Life of this patent
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Abstract
An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.
Claims26
An agent for regulating 14273 receptor function comprising a compound having an aromatic ring and a group capable of releasing a cation.
An agent for preventing or treating diabetes mellitus, hyperlipidemia, obesity or anorexia, comprising a 14273 receptor function regulating drug having an aromatic ring and a group capable of releasing a cation.
An agent for regulating stress comprising a compound having an aromatic ring and a group capable of releasing a cation.
A compound represented by the formula:
- wherein Ra is a hydrogen atom, a fluorine atom, a chlorine atom, a hydrocarbon group optionally having substituent(s), a heterocyclic group optionally having substituent(s), a hydroxy group optionally having substituent(s), a carboxyl group optionally having substituent(s), an acyl group, or an amino group optionally having substituent(s);
- Rb is a hydrogen atom, a fluorine atom, a chlorine atom, a hydrocarbon group optionally having substituent(s), a heterocyclic group optionally having substituent(s), a hydroxy group optionally having substituent(s), a carboxyl group optionally having substituent(s), an acyl group, or an amino group optionally having substituent(s),
- with the proviso that when one of Ra and Rb is a hydrogen atom, then the other should not be a hydrogen atom;
- Rc is a hydrogen atom, a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s);
- Rd is a hydrogen atom, a fluorine atom, a chlorine atom, a hydrocarbon group optionally having substituent(s), a heterocyclic group optionally having substituent(s), a hydroxy group optionally having substituent(s), a carboxyl group optionally having substituent(s), an acyl group, or an amino group optionally having substituent(s),
- or Rc and Rd are optionally bonded to each other to form a ring optionally having substituent(s);
- Re is a hydrogen atom, a fluorine atom, a chlorine atom, hydrocarbon group optionally having substituent(s), a heterocyclic group optionally having substituent(s), a hydroxy group optionally having substituent(s), a carboxyl group optionally having substituent(s), an acyl group, or an amino group optionally having substituent(s),
- with the proviso that when one of Rd and Re is a hydrogen atom, then the other should not be a hydrogen atom;
- Xa is an oxygen atom, or a methylene group optionally having substituent(s);
- and
- ring C is a benzene ring optionally having further substituent(s),
- or a salt thereof, except
- (i) 3,5-difluoro-4-[(2,3-dihydro-1H-inden-1-yl)oxy]benzenepropanoic acid, (ii) 3-chloro-4-[(2,3-dihydro-1H-inden-1-yl)oxy]benzenepropanoic acid, (iii) 4-([1,1′-biphenyl]-3-ylmethoxy)-3-chlorobenzenepropanoic acid, (iv) 4-[(4,5-dimethoxy-2-nitrophenyl)methoxy]-3-methoxybenzenepropanoic acid, and (v) 4-[3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propoxy]-3-methoxybenzenepropanoic acid.
3,5-Difluoro-4-[(3-phenoxyphenyl)methoxy]-benzenepropanoic acid, or 3-fluoro-4-[(3-phenoxyphenyl)methoxy]benzenepropanoic acid, or a salt thereof.
3-(4-{[3-(4-Chlorophenoxy)benzyl]oxy}-3,5-difluorophenyl)propanoic acid, 3-(3,5-difluoro-4-{[3-(4-fluorophenoxy)benzyl]oxy}phenyl)propanoic acid, 3-(3,5-difluoro-4-{[3-(4-methylphenoxy)benzyl]oxy}phenyl)propanoic acid, 3-(3-fluoro-4-{[3-(2-fluorophenoxy)benzyl]oxy}phenyl)-propanoic acid, 3-(3-fluoro-4-{[3-(3-fluorophenoxy)benzyl]-oxy}phenyl)propanoic acid, 3-(3-fluoro-4-{[3-(4-fluorophenoxy)benzyl]oxy}phenyl)propanoic acid, 3-(3-fluoro-4-{[3-(4-chlorophenoxy)benzyl]oxy}phenyl)propanoic acid, 3-(3-fluoro-4-{[3-(4-methylphenoxy)benzyl]oxy}phenyl)propanoic acid, 3-{3-methyl-4-[(3-phenoxybenzyl)oxy]phenyl}propanoic acid, or 3-(4-{[3-(4-fluorophenoxy)benzyl]oxy}-3-methylphenyl)propanoic acid, or a salt thereof.
A method of regulating the function of 14273 receptor, comprising administering, to a mammal, an effective amount of a compound having an aromatic ring and a group capable of releasing a cation.
A method of preventing or treating diabetes mellitus, hyperlipidemia, obesity or anorexia, comprising regulating the function of 14273 receptor by administering, to a mammal, an effective amount of a compound having an aromatic ring and a group capable of releasing a cation.
A method of regulating stress, comprising administering, to a mammal, an effective amount of a compound having an aromatic ring and a group capable of releasing a cation.
Use of a compound having an aromatic ring and a group capable of releasing a cation, for the production of an agent for regulating 14723 receptor function.
Use of a 14273 receptor function regulating drug having an aromatic ring and a group capable of releasing a cation, for the production of an agent for the prevention or treatment of diabetes mellitus, hyperlipidemia, obesity or anorexia.
Use of a compound having an aromatic ring and a group capable of releasing a cation, for the production of a stress regulating agent.
A method of screening for a ligand, agonist or antagonist for a 14273 receptor, comprising using a 14273 receptor, or a partial peptide thereof or a salt thereof, and a compound having an aromatic ring and a group capable of releasing a cation.
A kit for screening for a ligand, agonist or antagonist for a 14273 receptor, comprising a 14273 receptor, or a partial peptide thereof or a salt thereof, and a compound having an aromatic ring and a group capable of releasing a cation.
Dependencies are inferred from the claim text.