Methods and products which utilize N-acyl-L-aspartic acid
AssigneeDmi Biosciences, Inc.
InventorsDavid Bar-Or, Leonard T. Rael
Life of this patent
Estimating the term…
Abstract
The invention provides therapeutic methods and products for the treatment of inflammation, inflammatory diseases and conditions, and proliferative diseases and conditions. The invention also provides methods and products for inhibiting inflammation in excised cells, tissues and organs. The invention further provides oral care methods and products for the treatment of the tissues of an animal's mouth. Finally, the invention provides personal care methods and products for the treatment of the skin of an animal. All of these methods and products utilize N-acyl-L-aspartic acid or an ester or pharmaceutically-acceptable salt thereof.
Claims24
1-62. (canceled)
A method of treating inflammation of a tissue or an organ of an animal comprising administering to the animal an effective amount of a compound of the formula:
- R1—C(O)—NH—CH2(CH2—COOR2)—COOR2
- wherein:
- R1 is H, a lower alkyl or a lower alkyl substituted with a halogen atom;
- and
- R2, each of which may be the same or different, is H or an alkyl, cycloalkyl, aryl, alkylaryl
- or arylalkyl, each of which may optionally be substituted with a polar substitutent;
- or a pharmaceutically-acceptable salt thereof.
A method of treating an inflammatory disease or condition of an animal other than an inflammatory disease or condition of the animal's skin, the method comprising administering to the animal an effective amount of a compound of the formula:
- R1—C(O)—NH—CH2(CH2—COOR2)—COOR2
- wherein:
- R1 is H, a lower alkyl or a lower alkyl substituted with a halogen atom;
- and
- R2, each of which may be the same or different, is H or an alkyl, cycloalkyl, aryl, alkylaryl
- or arylalkyl, each of which may optionally be substituted with a polar substitutent;
- or a pharmaceutically-acceptable salt thereof.
A pharmaceutical composition formulated for administration to an animal other than by topical administration to the animal's skin, the composition comprising a pharmaceutically-acceptable carrier and a compound of the formula:
- R1—C(O)—NH—CH2(CH2—COOR2)—COOR2
- wherein:
- R1 is H, a lower alkyl or a lower alkyl substituted with a halogen atom;
- and
- R2, each of which may be the same or different, is H or an alkyl, cycloalkyl, aryl, alkylaryl
- or arylalkyl, each of which may optionally be substituted with a polar substitutent;
- or a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.