Multidrug multiligand conjugates for targeted drug delivery
OwnerAhmad Safavyinventor
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Abstract
Described is a multi drug multiligand conjugate for targeted drug delivery. The MDML conjugate contains a plurality of tripartite molecules linked to a central scaffold moiety, with each tripartite molecule comprising a targeting molecule, a therapeutic agent and a scaffold binding element. The MDML conjugate allows for more efficient delivery of therapeutic agents to the cells resulting in enhanced therapeutic efficiency. A model MDL conjugate is disclosed as well as method for the synthesis of the model conjugate.
Claims20
A method of treating an individual having a disease comprising the step of administering to the individual in an amount sufficient to treat the disease a compound comprising a plurality of tripartite molecules linked to a scaffold moiety, with each tripartite molecule comprising a targeting molecule for directing the compound to a defined population of cells, a therapeutic agent and a scaffold binding element capable of complementary interaction with the scaffold moiety, each of the targeting molecule, the therapeutic agent and the scaffold binding element being joined by a linker molecule to a central core molecule, the targeting molecule and the therapeutic agent being selected based on the disease to be treated.
Dependencies are inferred from the claim text.