Substituted Pyrroles, Compositions Containing Same, Method for Making Same and Use Thereof

A compound of formula (I):

• in which:
• 1) A and Ar are independently selected from the group consisting of:
• aryl, heteroaryl, heterocyclyl, substituted aryl, substituted heteroaryl, substituted heterocyclyl, cycloalkyl, and substituted cycloalkyl;
• 2) L is selected from the group consisting of:
• NH, CO—NH, NH—CO, NH—SO2, SO2NH, NH—CH2, CH2—NH, CH2—CO—NH, NH—CO—CH2, NH—CH2—CO, CO—CH2—NH, NH—CO—NH, NH—CS—NH, NH—CO—O, O—CO—NH, CH2—NH—CO—NH, NH—CO—NH—CH2, and NH—CO—CH2—CO—NH;
• 3) Ra is selected from the group consisting of H, alkyl and cycloalkyl;
• 4) R1 is selected from the group consisting of:
• H, R, COR, and SO2R, in which R is chosen from H, OR″4, NR″5R″6, (C1-C6)alkyl, cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl, in which R″4 is chosen from H, phenyl, and alkyl, and in which R″5 and R″6 are independently selected from the group consisting of H, R OR″4, (C1-C6)alkyl, cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl or alternatively R″5 and R″6 are linked to each other to form a 5- to 8-membered saturated ring containing from 0 to 3 heteroatoms chosen from O, S and N;
• 5) R2 and R5 are independently selected from the group consisting of:
• H, halogen, R′2, CN, O(R′2), OC(O)(R′2), OC(O)N(R′2)(R′3), OS(O2)(R′2), N(R′2)(R′3), N═C(R′2)(R′3), N(R′2)C(O)(R′3), N(R′2)C(O)O(R′3), N(R′4)C(O)N(R′2)(R′3), N(R′4)C(S)N(R′2)(R′3), N(R′2)S(O2)(R′3), C(O)(R′2), C(O)O(R′2), C(O)N(R′2)(R′3), C(═N(R′3))(R′2), C(═N(OR′3))(R′2), S(R′2), S(O)(R′2), S(O2)(R′2), S(O2)O(R′2), and S(O2)N(R′2)(R′3);
• in which each R′2, R′3, R′4 is independently selected from the group consisting of H, alkyl, alkylene, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, substituted alkyl, substituted alkylene, substituted alkynyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl, and substituted heterocyclyl;
• in which, when R′2 and R′3 are each different from H and simultaneously present on R2 or on R3, they may be linked to each other to form a ring containing from 0 to 3 heteroatoms chosen from O, S and N;
• or a pharmaceutically acceptable salt thereof.