Arylsulfonyl pyrrolidines as 5-HT6 inhibitors

A compound of formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• m is from 0 to 4;
• n is from 0 to 2;
• Ar is optionally substituted aryl or optionally substituted heteroaryl;
• R1 is:
• hydrogen;
• C1-6alkyl;
• hetero-C1-6alkyl;
• or
• —(CH2)p—X—(CH2)q—Ra;
• wherein:
• X is —C(O)— or —SO2—;
• p and q each independently is 0 or 1;
• and
• Ra is:
• C1-6alkyl;
• C1-6alkoxy;
• halo-C1-6alkyl;
• halo-C1-6alkoxy;
• hydroxy;
• amino;
• N—C1-6alkyl-amino;
• or
• N,N-di-C1-6alkylamino;
• and
• each R2 is independently:
• halo;
• C1-6alkyl;
• halo-C1-6alkyl;
• halo-C1-6alkoxy;
• C1-6alkoxy;
• hydroxy;
• hetero-C1-6alkyl;
• cyano;
• nitro;
• amino;
• N—C1-6alkyl-amino;
• N,N-di-C1-6alkylamino;
• or
• —(CH2)r—Y—(CH2)s-Z-(CH2)t-Q-(CH2)u—Rb;
• wherein
• r, s, t and u each independently is 0 or 1;
• Z is —C(O)— or —SO2—;
• X and Y each independently is —O—, —NRc— or a bond;
• Rb is:
• hydrogen;
• C1-6alkyl;
• halo-C1-6alkyl;
• halo-C1-6alkoxy;
• C1-6alkoxy;
• hydroxy;
• hetero-C1-6alkyl;
• cyano;
• amino;
• C1-6alkyl-amino;
• or
• N,N-di-C1-6alkylamino;
• and
• Rc is:
• hydrogen;
• or
• C1-6alkyl.