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US 2008/0167359 A1Published application
N-Substituted (Benzoimidazol-2-yl)phenylamines, Processes for Their Preparation, Their Use as a Medicament or Diagnostic Aid, and a Medicament Comprising Them
AssigneeSanofi-Aventis Deutschland GmbH
InventorsUwe HEINELT, Hans-Jochen LANG, Armin HOFMEISTER, Klaus WIRTH, Martin HUG
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Abstract
This invention is directed to the compound of formula (I), compositions containing said compounds to inhibit the sodium-proton exchanger of subtype 3 (NHE3) which are useful in the prevention or treatment of various disorders in a patient suffering from a disease state, such as, renal disorders including acute or chronic renal failure, disorders of biliary function and for respiratory disorders such as snoring or sleep apnea or for stroke.
Claims13
A compound of formula I
- wherein,
- R1 and R4 are independently selected from the group consisting of H, F, Cl, Br, C1-C4-alkyl and C1-C4-alkoxy wherein, the C1-C4-alkyl and C1-C4-alkoxy are optionally substituted independently of one another by 1, 2, 3, 4, 5, 6, 7, 8 or 9 fluorine atoms;
- R2 and R3 are independently selected from the group consisting of H, F, OH, C1-C3-alkyl, and C1-C3-alkoxy wherein, the C1-C3-alkyl and C1-C3-alkoxy are optionally substituted independently of one another by 1, 2, 3, 4, 5, 6 or 7 fluorine atoms;
- R5 is independently selected from the group consisting of C1-C4-alkyl, C2-C4-alkenyl and C3-C5-cycloalkyl, wherein, the C1-C4-alkyl, C2-C4-alkenyl and C3-C5-cycloalkyl are optionally substituted by 1, 2, 3, 4, 5, 6, 7, 8 or 9 fluorine atoms;
- and
- R6 and R7 are independently selected from the group consisting of H, F, Cl, Br, C1-C4-alkyl and C1-C3-alkoxy, wherein, the C1-C4-alkyl and C1-C3-alkoxy are optionally substituted independently of one another by 1, 2, 3, 4, 5, 6, 7, 8 or 9 fluorine atoms,
- provided that R6 and R7 are not simultaneously hydrogen;
- or the pharmaceutically acceptable salt, or trifluoroacetic acid salt thereof.
5 more elements
Dependencies are inferred from the claim text.