Compounds Which Potentiate Glutamate Receptor and Uses Thereof in Medicine

A compound of formula (I), or a salt, or solvate thereof

• wherein
• R1 is selected from C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino and diC1-4alkylamino;
• R2, R3 and R6, which may be the same or different, are each independently selected from hydrogen, halogen, C1-6alkyl, haloC1-6alkyl and C1-4alkoxy;
• each R4, which may be the same or different, is selected from C1-6alkyl, halogen, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy and cyano;
• p is selected from 0, 1 and 2;
• and
• R5 is phenyl or an aromatic heterocyclyl, either of which is optionally substituted with one or more groups Y;
• each Y group is independently selected from the group consisting of:
• C1-6alkyl, halogen, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, —(CH2)qNR5aSO2R5b, —(CH2)qNR5a(C═O)R5d, —(CH2)qNR5a(C═O)N(R5c)2, —(CH2)q(C═O)R5d, —(CH2)qSO2R5b;
• where R5a and each R5c, which may be the same or different, is selected from hydrogen and C1-6alkyl;
• R5b is selected from C1-6alkyl and haloC1-6alkyl;
• R5d is selected from C1-6alkyl, C1-4alkoxy and haloC1-6alkyl;
• or R5a and R5b, R5a and R5c, or R5a and R5d, where appropriate, together with the interconnecting atoms, may form a 5- or 6-membered ring;
• and q is 0, 1, or 2;
• in the case when there are two or more Y groups present, two of them together may form a cyclic group selected from —(CH2)rOR5eO(CH2)s— and —(CH2)tOR5e— where R5e is a group selected from C1-4alkylene or halo C1-4alkylene;
• r and s are each independently 0, 1 or 2;
• and t is 2 or 3.