Amide substituted indazoles as poly(ADP-ribose)polymerase(PARP) inhibitors
AssigneeInstituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A.
InventorsPhilip Jones, Jesus Maria Ontoria Ontoria, Rita Scarpelli, Carsten Schultz-Fademrecht
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Abstract
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo- and/or radiosensitizers for cancer treatment.
Claims16
A compound of formula I:
- wherein:
- R1 is hydrogen or fluorine;
- and
- R2 is hydrogen or fluorine;
- or pharmaceutically acceptable salts, stereoisomers or tautomers thereof.
A compound of any previous claim wherin R1 is hydrogen and R2 is hydrogen or fluorine.
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Dependencies are inferred from the claim text.