Azolopyridin-2-one derivatives as lipase and phospholipase inhibitors

A compound of formula I

• wherein:
• X is independently selected from ═C(—R)— and ═N—, with the proviso that at least one and at most two of X is ═N—;
• Y is —O— or —S—;
• R is independently selected from hydrogen, halogen, (C1-C6)-alkyl, (C1-C3)-alkyloxy-(C1-C3)-alkylene, hydroxy, (C1-C6)-alkylmercapto, amino, (C1-C6)-alkylamino, di-(C2-C12)-alkylamino, (C1-C6)-alkylcarbonyl, COOR3, trifluoromethyl, (C1-C6)-alkylsulfonyl, (C1-C6)-alkylsulfinyl, aminosulfonyl, pentafluorosulfanyl, (C6-C10)-aryl, (C5-C12)-heteroaryl, CO—NR6R7, O—CO—NR6R7, O—CO—(C1-C6)-alkylene-CO—O—(C1-C6)-alkyl, O—CO—(C1-C6)-alkylene-CO—OH, O—CO—(C1-C6)-alkylene-CO—NR6R7 and unsubstituted or mono- or poly-F-substituted (C1-C6)-alkyloxy;
• R1 is selected from (C4-C16)-alkyl, (C1-C4)-alkylene-(C6-C10)-aryl, (C1-C4)-alkylene-(C5-C12)-heteroaryl, (C1-C4)-alkylene-(C3-C12)-cycloalkyl, and (C8-C14)-bicycle, wherein each of said aryl, heteroaryl, cycloalkyl and bicycle may be substituted one or more times by a substituent selected from halogen, (C1-C6)-alkyl, (C1-C3)-alkyloxy, hydroxy, (C1-C6)-alkylmercapto, amino, (C1-C6)-alkylamino, di-(C2-C12)-alkylamino, mono-(C1-C6)-alkylaminocarbonyl, di-(C2-C8)-alkylaminocarbonyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkylcarbonyl, cyano, trifluoromethyl, trifluoromethyloxy, (C1-C6)-alkylsulfonyl, and aminosulfonyl;
• R2 is selected from hydrogen and (C1-C6)-alkyl;
• or, in the alternative,
• R1 and R2 form, together with the nitrogen atom to which they are attached, a monocyclic, saturated or partially unsaturated 4- to 7-membered ring system or a bicyclic saturated or partially unsaturated 8- to 14-membered ring system, of which individual members of the ring systems may be replaced by one to three atoms or atomic groups selected from —CHR4-, —CR4R5-, —(C═R4)-, —NR6-, —C(═O)—, —O—, —S—, —SO—, —SO2—, with the proviso that no two of the units —O—, —S—, —SO—, and —SO2— may be adjacent to each other;
• R3 is hydrogen, (C1-C6)-alkyl, or benzyl;
• R4 and R5 are independently selected from (C1-C6)-alkyl, halogen, trifluoromethyl, COOR3, cyclopropyl, and cyclopropylene;
• and
• R6 and R7 are independently selected from hydrogen, (C1-C6)-alkyl, —(C6-C10)-aryl, (C5-C12)-heteroaryl, (C3-C12)-cycloalkyl, (C1-C4)-alkylene-(C6-C10)-aryl, (C1-C4)-alkylene-(C5-C12)-heteroaryl, (C1-C4)-alkylene-(C4-C12)-cycloalkyl, and (C8-C14)-bicycle;
• or a tautomer or a salt thereof.