Compounds and methods for kinase modulation, and indications therefor

A compound having the chemical structure of Formula II,

• all salts, prodrugs, tautomers and isomers thereof,
• wherein:
• R1 is selected from the group consisting of hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —OH, —NH2, —CN, —NO2, —C(O)OH, —S(O)2NH2, —C(O)NH2, —C(S)NH2, —NHC(O)NH2, —NC(S)NH2, —NHS(O)2NH2, —OR4, —SR4, —NR5R4, —C(O)R4, —C(S)R4, —C(O)OR4, —C(O)NR5R4, —C(S)NR5R4, —S(O)2NR5R4, —NR5C(O)R4, NR5C(S)R4, —NR5S(O)2R4, —NR5C(O)NH2, —NR5C(O)NR5R4, —NR5C(S)NH2, —NR5C(S)NR5R4, —NR5S(O)2NH2, —NR5S(O)2NR5R4, —S(O)R4, and —S(O)2R4;
• R2a is selected from the group consisting of halogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —OH, —NH2, —CN, —NO2, —C(O)OH, —S(O)2NH2, —C(O)NH2, —C(S)NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —OR4, —SR4, —NR5R4, —C(O)R4, —C(S)R4, —C(O)OR4, —C(O)NR5R4, —C(S)NR5R4, —S(O)2NR5R4, —NR5C(O)R4, —NR5C(S)R4, —NR5S(O)2R4, —NR5C(O)NH2, —NR5C(O)NR5R4, —NR5C(S)NH2, —NR5C(S)NR5R4, —NR5S(O)2NH2, —NR5S(O)2NR5R4, —S(O)R4, and —S(O)2R4;
• R3 is selected from the group consisting of hydrogen, fluoro and chloro;
• R4 is selected from the group consisting of optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R4 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to N, S, O, S(O), S(O)2, C(O) or C(S) of —OR4, —SR4, —NR5R4, —C(O)R4, —C(S)R4, —C(O)OR4, —C(O)NR5R4, —C(S)NR5R4, —S(O)2NR5R4, —NR5C(O)R4, —NR5C(S)R4, —NR5S(O)2R4, —NR5C(O)NH2, —NR5C(O)NR5R4, —NR5C(S)NH2, —NR5C(S)NR5R4, —NR5S(O)2NH2, —NR5S(O)2NR5R4, —S(O)R4, or —S(O)2R4, optionally substituted lower alkynyl, provided, however, that when R4 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to N, S, O, S(O), S(O)2, C(O) or C(S) of —OR4, —SR4, —NR5R4, —C(O)R4, —C(S)R4, —C(O)OR4, —C(O)NR5R4, —C(S)NR5R4, —S(O)2NR5R4, —NR5C(O)R4, —NR5C(S)R4, —NR5S(O)—NR5C(O)N2, —NR5C(O)NR5R4, —NR5C(S)NH2, —NR5C(S)NR5R4, —NR5S(O)2NH2, —NR5S(O)2NR5R4, —S(O)R4, or —S(O)2R4, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• and
• R5 is selected from the group consisting of hydrogen and optionally substituted lower alkyl, provided, however, the compound is not

A compound having the chemical structure of Formula III,

• all salts, prodrugs, tautomers and isomers thereof,
• wherein:
• R1 is selected from the group consisting of hydrogen, halogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —OH, —NH2, —CN, —NO2, —C(O)OH, —S(O)2NH2, —C(O)NH2, —C(S)NH2, —NHC(O)NH2, —NHC(S)NH2, —NHS(O)2NH2, —OR4—SR4, —NR5R4, —C(O)R4, —C(S)R4, —C(O)OR4, —C(O)NR5R4, —C(S)NR5R4, —S(O)2NR5R4, —NR5C(O)R4, —NR5C(S)R4, —NR5S(O)2R4, —NR5C(O)NH2, —NR5C(O)NR5R4, —NR5C(S)NH2, —NR5C(S)NR5R4, —NR5S(O)2NH2, —NR5S(O)2NR5R4, —S(O)R4, and —S(O)2R4;
• R3 is selected from the group consisting of hydrogen, fluoro and chloro;
• R4 is selected from the group consisting of optionally substituted lower alkyl, optionally substituted lower alkenyl, provided, however, that when R4 is optionally substituted lower alkenyl, no alkene carbon thereof is bound to N, S, O, S(O), S(O)2, C(O) or C(S) of —OR4, SR4, —NR5R4C(O)R4, C(S)R4, —C(O)OR4, —C(O)NR5R4, —C(S)NR5R4, —S(O)2NR5R4, —NR5C(O)R4, NR5C(S)R4, —NR5S(O)2R4, —NR5C(O)NH2, —NR5C(O)NR5R4, —NR5C(S)NH2, —NR5C(S)NR5R4, —NR5S(O)2NH2, —NR5S(O)2SR5R4, —S(O)R4, or —S(O)2R4, optionally substituted lower alkynyl, provided, however, that when R4 is optionally substituted lower alkynyl, no alkyne carbon thereof is bound to N, S, O, S(O), S(O)2, C(O) or C(S) of —OR4, —SR4, —NR5R4, —C(O)R4—C(S)R4, —C(O)OR4, —C(O)NR5R4, —C(S)NR5R4, —S(O)2NR5R4, —NR5C(O)R4, —NR5C(S)R4, —NR5S(O)2R4, —NR5C(O)NH2, —NR5C(O)NR5R4, —NR5C(S)NH2, —NR5C(S)NR5R4, —NR5S(O)2NH2, —NR5S(O)2NR5R4, —S(O)R4, or —S(O)2R4, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl:
• R5 is selected from the group consisting of hydrogen and optionally substituted lower alkyl;
• and
• R6 is optionally substituted heteroaryl, provided, however, the compound is not