Novel sulfonamides
AssigneeAllergan, Inc.
InventorRobert M. Burk
Life of this patent
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Abstract
The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2 is selected from the group consisting of C1-C10 alkyl and (CH2)nOH; R3 is selected from the group consisting of C1-C10 alkyl, heteroaryl, e.g. thienyl, furanyl and pyridyl, phenyl, mono, -di-, tri-substituted phenyl and heteroaryl; R4 and R5 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl hydroxyl; m is 0 or an integer from 1 to 3 and n is an integer of from 1 to 4. These compounds are useful in lowering intraocular pressure and/or treating glaucoma or providing neuroprotection to the eye of a human patient.
Claims14
1-19. (canceled)
A method of providing neuroprotection to the eye of a mammal which comprises administering to the eye of said mammal a compound represented by the formula:
- wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5;
- R2 is selected from the group consisting of C1-C10 alkyl and (CH2)nOH;
- R3 is selected from the group consisting of C1-C10 alkyl, heteroaryl, phenyl, and mono, -di-, tri-substituted phenyl and heteroaryl;
- R4 and R5 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl hydroxyl;
- m is 0 or an integer from 1 to 3 and
- n is an integer of from 1 to 4.
The method of claim 21 wherein R3 is selected from the group consisting of thienyl, furanyl and pyridyl.
A compound represented by the formula:
- wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5;
- R2 is selected from the group consisting of C1-C10 alkyl and (CH2)nOH;
- R3 is selected from the group consisting of C1-C10 alkyl, heteroaryl, phenyl, and mono, -di-, tri-substituted phenyl and heteroaryl;
- R4 and R5 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl hydroxyl;
- m is 0 or an integer from 1 to 3 and
- n is an integer of from 1 to 4.
A method for treating ocular hypertension or glaucoma which comprises administering to a mammal having ocular hypertension a therapeutically effective amount of a compound of the formula
- wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5;
- R2 is selected from the group consisting of C1-C10 alkyl and (CH2)nOH;
- R3 is selected from the group consisting of C1-C10 alkyl, heteroaryl, phenyl, and mono, -di-, tri-substituted phenyl and heteroaryl;
- R4 and R5 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl hydroxyl and
- n is 0 or 1.
Dependencies are inferred from the claim text.