Carbamoylsulphoximides as protein kinase inhibitors

Compounds of the general formula (I),

• in which
• R1 is
• (i) hydrogen, halogen, cyano, nitro, —NR8R9, —NR7—C(O)—R12, —NR7—C(O)—OR12, —NR7—C(O)—NR8R9, —NR7—SO2—R2, —CF3 or —OCF3, or
• (ii) a C1-C6-alkyl, C2-C6-alkenyl, C1-C6-alkoxy or C2-C6-alkynyl radical which is optionally substituted one or more times, identically or differently, by hydroxy, —NR8R9, —NR7—C(O)—R12, —NR7—C(O)—OR12, —NR7—C(O)—NR8R9, —NR7—SO2—R12, cyano, halogen, C1-C6-alkoxy, —CF3 and/or —OCF3, or
• (iii) a phenyl or monocyclic heteroaryl ring which is optionally substituted one or more times, identically or differently, by hydroxy, —NR8R9, —NR7—C(O)—R12, —NR7—C(O)—OR12, —NR7—C(O)—NR8R9, —NR7—SO2—R12, cyano, halogen, —CF3, C1-C6-alkoxy, —OCF3 and/or C1-C6-alkyl,
• R2 is
• (i) hydrogen or
• (ii) a C1-C10-alkyl, C2-C10-alkenyl or C2-C10-alkynyl radical, a C3-C7-cycloalkyl, phenyl or naphthyl ring, a heterocyclyl ring having 3 to 8 ring atoms or a mono- or bicyclic heteroaryl ring,
• in each case optionally substituted one or more times, identically or differently, by
• a) halogen, hydroxy, —NR8R9, —NR7—C(O)—R12, —NR7—C(O)—OR12, —NR7—C(O)—NR8R9, —NR7—SO2—R12, cyano, —C(O)R6, —O(CO)—R12, —SO2NR8R9, —SO2—R12, —S(O)(NR8)R12, —(N)S(O)R13R14, —CF3, —OCF3, —N[(CO)—(C1-C6-alkyl)]2 and/or
• b) C1-C6-alkoxy, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, phenyl, naphthyl, heterocyclyl having 3 to 8 ring atoms and/or a monocyclic or bicyclic heteroaryl, in each case optionally themselves substituted one or more times, identically or differently, by halogen, hydroxy, a C1-C6-alkyl, C1-C6-alkoxy, —NR8R9, —C(O)OR16, —SO2NR8R9, —CF3 or —OCF3,
• R3 is
• (i) hydroxy, halogen, cyano, nitro, —CF3, —OCF3, —C(O)NR8R9, —C(S)NR8R9, —NR8R9, —NR7—C(O)—R12, —NR7—C(O)—OR12, —NR7—C(O)—NR8R9, —NR7—SO2—R12, and/or
• (ii) a C1-C6-alkyl and/or C1-C6-alkoxy radical which is optionally substituted one or more times, identically or differently, by halogen, hydroxy, C1-C6-alkoxy, —CF3, —OCF3 or —NR8R9, and/or
• (iii) a C3-C7-cycloalkyl ring which is optionally substituted one or more times, identically or differently, by halogen, hydroxy, C1-C6-alkoxy, —CF3, —OCF3, —NR8R9 and/or C1-C6-alkyl,
• m is 0-4,
• Z is the group —NH— or a direct linkage,
• R4 and R5 are independently of one another a C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl radical, a C3-C7-cycloalkyl or phenyl ring, a heterocyclyl ring having 3 to 8 ring atoms or a monocyclic heteroaryl ring, in each case optionally themselves substituted one or more times, identically or differently, by hydroxy, —NR8R9, cyano, halogen, —CF3, C1-C6-alkoxy, —OCF3 and/or C1-C6-alkyl, or
• R4 and R5 together with the sulphur form a 3 to 7-membered ring which is optionally substituted one or more times, identically or differently, by hydroxy, C1-C6-alkyl, C1-C6-alkoxy, halogen or —NR8R9, and optionally comprises a double bond,
• X is —O—, —S— or —NR15—,
• where
• R15 is
• (i) hydrogen or
• (ii) a C1-C6-alkyl radical, C3-C8-cycloalkyl or phenyl ring, a heterocyclyl ring having 3 to 8 ring atoms or a monocyclic heteroaryl ring, or
• (iii) —C(O)—(C1-C6)-alkyl, —C(O)-phenyl, or —C(O)-benzyl, and (ii) and (iii) are optionally substituted one or more times, identically or differently, by hydroxy, —NR10R11, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3, or
• if X is —NR15—, alternatively —NR15— and R2 together form a 3 to 8 membered ring which optionally comprises in addition to the nitrogen atom one or more further heteroatoms, is optionally substituted one or more times, identically or differently, by hydroxy, C1-C6-alkyl, C1-C6-alkoxy, —C(O)R12, —SO2R12, halogen or the group —NR8R9, optionally comprises 1 to 3 double bonds, and/or is optionally interrupted by one or more —C(O)— groups,
• Q is a phenyl, naphthyl or a monocyclic or bicyclic heteroaryl ring,
• R6 is
• (i) hydrogen or hydroxy, or
• (ii) a C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkynyl or C1-C6-alkoxy radical, a C3-C7-cycloalkyl or phenyl ring, a heterocyclyl ring having 3 to 8 ring atoms or a monocyclic heteroaryl ring, in each case optionally themselves substituted one or more times, identically or differently, by hydroxy, —NR8R9, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3,
• R7 is hydrogen or a C1-C6-alkyl radical, R8 and R9 are independently of one another
• (i) hydrogen and/or
• (ii) a C1-C6-alkyl radical, C2-C6-alkenyl, C3-C8-cycloalkyl and/or phenyl ring, a heterocyclyl ring having 3 to 8 ring atoms and/or a monocyclic heteroaryl ring, optionally substituted one or more times, identically or differently, by hydroxy, —NR10R11, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3, or
• R8 and R9 together with the nitrogen atom form a 5- to 7-membered ring which optionally comprises in addition to the nitrogen atom 1 or 2 further heteroatoms, and which may be substituted one or more times, identically or differently, by hydroxy, —NR10R11, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3,
• R10 and R11 are independently of one another hydrogen or a C1-C6-alkyl radical which is optionally substituted one or more times, identically or differently, by hydroxy, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3,
• R12, R13, R14 are independently of one another a C1-C6-alkyl, C2-C6-alkenyl and/or C2-C6-alkynyl radical, a C3-C7-cycloalkyl or phenyl ring, a heterocyclyl ring having 3 to 8 ring atoms or a monocyclic heteroaryl ring, optionally in each case themselves substituted one or more times, identically or differently, by hydroxy, nitro, —NR8R9, cyano, halogen, —CF3, C1-C6-alkyl, C1-C6-alkoxy and/or —OCF3,
• R16 is
• (i) hydrogen or
• (ii) a C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkynyl radical, a C3-C7-cycloalkyl or phenyl ring, a heterocyclyl ring having 3 to 8 ring atoms or a monocyclic heteroaryl ring, in each case optionally themselves substituted one or more times, identically or differently, by hydroxy, —NR8R9, cyano, halogen, —CF3, C1-C6-alkoxy and/or —OCF3,
• and the salts, diasteriomers thereof.