Hydrates of erlotinib hydrochloride
AssigneeSynthon BV
InventorRaymond J. H. Westheim
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Abstract
Erlotinib hydrochloride hydrate is formed from an aqueous solution and is useful as a pharmaceutical and as a purification intermediate.
Claims19
A crystalline erlotinib hydrochloride hydrate.
A process for the preparation of a hydrate of erlotinib hydrochloride, which comprises crystallizing an erlotinib hydrochloride hydrate from an aqueous solution of erlotinib hydrochloride.
A process for treating cancer, which comprises administering an effective amount of a crystalline erlotinib hydrochloride hydrate to a patient in need thereof.
A process for making crystalline erlotinib anhydrate, which comprises crystallizing an erlotinib hydrochloride hydrate from an aqueous solution of erlotinib hydrochloride;
- and recrystallizing said erlotinib hydrochloride hydrate from a non-aqueous solvent system to form an anhydrous erlotinib hydrochloride of Form A, Form B, or Form E.
Dependencies are inferred from the claim text.