Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain

A substituted tetrahydropyrrolopyrazine compound corresponding to formula I:

• wherein
• R1, R2 and R3 independently of one another represent hydrogen, saturated or unsaturated branched or unbranched C1-6-alkyl which is unsubstituted or mono- or poly-substituted, F, Cl, Br, I, CN, NH2, NH—C1-6-alkyl, NH—C1-6-alkyl-OH, N(C1-6alkyl)2, N(C1-6-alkyl-OH)2, NH-aryl, NH-alkylaryl, NH-heteroaryl, NO2, SH, S—C1-6-alkyl, OH, O—C1-6-alkyl, O—C1-6alkyl-OH, C(═O)C1-6-alkyl, NHSO2C1-6-alkyl, NHCOaryl;
• NHCOC1-6-alkyl, CO2H, CH2SO2-phenyl, CO2—C1-6-alkyl, OCF3, CF3, benzyloxy, morpholinyl, pyrrolidinyl, piperidinyl, piperazinyl, phenoxy, phenyl, pyridyl, alkylaryl, thienyl or furyl;
• or
• R1 and R2 or R2 and R3 form a ring and together denote
• R4 and R5 independently of one another represent H, F, Cl, Br, I, —CN, NH2, NH—C1-6-alkyl, NH—C1-6-alkyl-OH, C1-6-alkyl, N(C1-6-alkyl)2, N(C1-6-alkyl-OH)2, NO2, SH, S—C1-6-alkyl, S-benzyl, O—C1-6-alkyl, OH, O—C1-6-alkyl-OH, O-benzyl, C(═O)C1-6-alkyl, CO2H, CO2—C1-6-alkyl or benzyl;
• R6 represents branched or unbranched C1-6-alkyl which is unsubstituted or mono- or poly-substituted, aryl or heteroaryl which are unsubstituted or mono- or poly-substituted, or unsubstituted or mono- or poly-substituted aryl or heteroaryl linked via a C1-3-alkyl chain;
• R4a, R5a and R6a independently of one another represent H or C1-6-alkyl;
• and
• R7 represents (CH2)tC(═O)R8, (C═O)(CH2)mNR11R12, C(═O)(CH2)n(C═O)R8 or (CH2)sNHC(═O)R8, wherein
• m represents 1, 2 or 3;
• n, t and s each represents 1, 2, 3 or 4;
• R8 denotes C1-6-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or poly-substituted;
• aryl, heteroaryl, heterocyclyl or C3-8-cycloalkyl, in each case unsubstituted or mono- or poly-substituted;
• or aryl, heteroaryl, heterocyclyl or C3-8-cycloalkyl linked via a C1-5-alkyl chain and in each case unsubstituted or mono- or poly-substituted, wherein the alkyl chain in each case can be saturated or unsaturated, branched or unbranched;
• NR9R10;
• wherein
• R9 and R10 independently of one another represent H;
• C1-6-alkyl, in each case saturated or unsaturated, branched or unbranched, mono- or poly-substituted or unsubstituted;
• aryl or heteroaryl, in each case unsubstituted or mono- or poly-substituted;
• heterocyclyl or C3-8-cycloalkyl, in each case saturated or unsaturated, mono- or poly-substituted or unsubstituted;
• C(═O)R2;
• SO2R13;
• or aryl, C3-8-cycloalkyl, heterocyclyl or heteroaryl bonded via C1-3-alkyl and in each case mono- or poly-substituted or unsubstituted, wherein the alkyl chain in each case can be saturated or unsaturated, branched or unbranched;
• or
• R9 and R10 together represent CH2CH2OCH2CH2, CH2CH2NR14CH2CH2 or (CH2)3-6;
• R11 and R12 independently of one another represent H, saturated or unsaturated branched or unbranched C1-6-alkyl which is unsubstituted or mono- or poly-substituted, heterocyclyl or C3-8-cycloalkyl in each case saturated or unsaturated and mono- or poly-substituted or unsubstituted, C(═O)R20, SO2R13, or aryl, C3-8-cycloalkyl, heterocyclyl or heteroaryl bonded via C1-3-alkyl and in each case mono- or poly-substituted or unsubstituted, wherein the alkyl chain in each case can be saturated or unsaturated, branched or unbranched;
• or
• R11 and R12 together represent CH2CH2OCH2CH2, CH2CH2NR14CH2CH2 or (CH2)3-6, wherein
• R14 denotes H, saturated or unsaturated branched or unbranched C1-6-alkyl which is unsubstituted or mono- or poly-substituted, saturated or unsaturated C3-8-cycloalkyl which is unsubstituted or mono- or poly-substituted, aryl or heteroaryl which are unsubstituted or mono- or poly-substituted, C(═O)R13, or aryl, C3-8-cycloalkyl or heteroaryl bonded via C1-3-alkyl and in each case mono- or poly-substituted or unsubstituted;
• R13 denotes saturated or unsaturated branched or unbranched C1-6-alkyl which is unsubstituted or mono- or poly-substituted;
• aryl, heteroaryl or C3-8-cycloalkyl, in each case unsubstituted or mono- or poly-substituted;
• or aryl, heteroaryl or C3-8-cycloalkyl linked via a saturated or unsaturated branched or unbranched C1-5-alkyl chain and in each case unsubstituted or mono- or poly-substituted;
• and
• R20 denotes saturated or unsaturated branched or unbranched C1-6-alkyl which is unsubstituted or mono- or poly-substituted;
• aryl, heteroaryl or C3-8-cycloalkyl, in each case unsubstituted or mono- or poly-substituted;
• NR21R22;
• or aryl, heteroaryl or C3-8-cycloalkyl linked via a saturated or unsaturated branched or unbranched C1-5-alkyl chain and in each case unsubstituted or mono- or poly-substituted, wherein
• R21 and R22 independently of one another denote saturated or unsaturated branched or unbranched C1-6-alkyl which is unsubstituted or mono- or poly-substituted;
• aryl, heteroaryl or C3-8-cycloalkyl, in each case unsubstituted or mono- or poly-substituted;
• or aryl, heteroaryl or C3-8-cycloalkyl linked via a saturated or unsaturated branched or unbranched C1-5-alkyl chain and in each case unsubstituted or mono- or poly-substituted;
• in the form of a pure stereoisomer or a mixture of stereoisomers in any mixing ratio;
• or a physiologically acceptable salt thereof.