Modulators of peroxisome proliferator activated receptors (ppar)

A compound of formula I,

• and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, wherein:
• n1 is 2, 3, 4 or 5;
• V is a bond or O;
• X is CH2 or O;
• p is 0 or 1;
• m is 1-4;
• Y1 is:
• wherein,
• is:
• 1-3-thiazolyl,
• wherein 1-3-thiazolyl are optionally substituted with one or more groups independently selected from the group consisting of:
• hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halo, haloalkyl and haloalkyloxy;
• Y1a is:
• hydrogen,
• (C0-C3)alkyl-aryl,
• C(O)-aryl,
• heteroaryl,
• cycloalkyl,
• heterocycloalkyl,
• aryloxy,
• NR5(CH2)mOR5,
• aryl-Z-aryl,
• aryl-Z-heteroaryl,
• aryl-Z-cycloalkyl,
• aryl-Z-heterocycloalkyl,
• heteroaryl-Z-aryl,
• heteroaryl-Z-heterocycloalkyl or
• heterocycloalkyl-Z-aryl,
• wherein aryl, cycloalkyl, aryloxy, heteroaryl, and heterocycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of:
• halo,
• hydroxyl,
• nitro,
• cyano,
• C1-C6 alkyl,
• C1-C6 alkoxy optionally substituted with N(R5)2,
• haloalkyl,
• N(R5)2,
• N[C(O)R5]2,
• N[S(O)2R5]2,
• NR5S(O)2R5,
• NR5C(O)R5,
• NR5C(O)OR5,
• C(O)N(R5)2,
• C(O)OR5 and
• C(O)R;
• Z is:
• a bond,
• -oxygen-
• —C(O)NR5—
• —NR5C(O)—,
• —NR5C(O)O—,
• —C(O)—,
• —NR5—,
• —[O]p(CH2)m—,
• —(CH2)m[O]p—,
• —NR5(CH2)m— or
• —(CH2)m NR5—;
• Y2 and Y3 are each independently:
• hydrogen,
• C1-C6 alkyl or
• C1-C6 alkoxy;
• Y4 is:
• (C1-C3)alkyl-NR5C(O)—(C0-C5)alkyl-Y7,
• (C1-C3)alkyl-NR5C(O)—(C2-C5)alkenyl-Y7,
• (C1-C3)alkyl-NR5C(O)—(C2-C5)alkynyl-Y7;
• (C1-C3)alkyl-NR5C(O)O—(C0-C5)alkyl-Y7,
• (C1-C3)alkyl-NR5C(O)NR5—(C0-C5)alkyl-Y7,
• (C1-C3)alkyl-NR5C(S)NR5—(C0-C5)alkyl-Y7,
• (C0-C3)alkyl-C(O)NR5—(C0-C5)alkyl-Y7,
• (C1-C3)alkyl-OC(O)NY10Y11,
• (C1-C3)alkyl-NY10Y11,
• (C1-C3)alkyl-O—(C0-C5)alkyl-Y7,
• (C1-C3)alkyl-S—(C0-C5)alkyl-Y7 or
• CN;
• Y7 is:
• hydrogen,
• aryl,
• heteroaryl,
• C1-C12 alkyl,
• C1-C6 alkoxy,
• cycloalkyl,
• heterocycloalkyl,
• aryloxy,
• C(O)-heteroaryl or
• SR6,
• wherein alkyl, aryl, aryloxy, alkoxy, heteroaryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more groups independently selected from R7:
• Y10 and Y11 are each independently:
• hydrogen,
• aryl,
• heteroaryl,
• C1-C10 alkyl,
• cycloalkyl,
• SO2(R6);
• or
• Y10 and Y11 together are a 5- to 10-membered heterocycloalkyl ring or heterocycloalkyl ring fused with aryl, and the heterocycloalkyl ring optionally containing one or more heteroatoms selected from N, O or S;
• and wherein, aryl, heteroaryl, heterocycloalkyl and alkyl are optionally substituted with one or more substituents independently selected from R7;
• R5 is:
• hydrogen or C1-C6 alkyl;
• R6 is:
• hydrogen,
• C1-C10 alkyl,
• cycloalkyl,
• aryl, or
• heteroaryl,
• wherein alkyl, cycloalkyl, aryl and heteroaryl are optionally substituted with one or more substituents independently selected from R7;
• R7 is:
• halo,
• nitro,
• oxo,
• cyano,
• hydroxyl,
• benzyl,
• phenyl,
• phenoxy,
• heteroaryl,
• C(O)R6,
• C1-C10 alkyl,
• C1-C6 alkoxy,
• C1-C6 haloalkyl,
• C1-C6 haloalkyloxy,
• O(CH2)m-phenyl,
• (CH2)mOC(O)-aryl,
• C(O)OR5,
• S(O)2R5,
• S(O)2N(R5)2,
• SR5 or
• N(R5)2,
• wherein phenyl and phenoxy are optionally substituted with one or more groups independently selected from halo or trifluoromethyl.