Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors

A compound having the structure of Formula (1) or Formula (46):

• wherein:
• Ar is a group comprising a moiety selected from an optionally substituted five-membered aromatic heterocycle, an optionally substituted five-membered aromatic carbocycle, an optionally substituted six-membered aromatic heterocycle, and a substituted, optionally further substituted phenyl;
• Q is a group comprising a non-aromatic tertiary amine or a non-aromatic secondary amine, with the proviso that Q is not —NRaRb or —SO2NRaRb;
• wherein each of Ra and Rb is independently H or C1-6alkyl optionally substituted by mono- or di-alkyl (C1-6) amino;
• each R1 is independently an optionally substituted moiety selected from -L1-H or -L1-C1-6alkyl;
• wherein L1 is selected from a bond, —O—, —NH—, —S—, —C(O)—, —C(S)—, —C(O)O—, —C(O)NH—,
• —S(O)—, —S(O)2—, C(O)NH(CR″2)1-6C(O)O—, —C(O)NR″NR″C(O)O—, and —S(O)NH—;
• each R″ is independently H, OH, halogen, C1-6alkyl, substituted C1-6alkyl, C1-6alkoxy, halo-C1-6alkyl, halo-C1-6alkoxy, aryl, haloaryl, or heteroaryl;
• or any two adjacent R1 groups together may form, an optionally substituted 5 to 8-membered heterocyclic, cycloalkyl, or aryl ring;
• R5 is H or C1-6alkyl;
• or a pharmaceutically acceptable salt or pharmaceutically acceptable N-oxide thereof.