Novel Heteroaryl Derivative
AssigneeDainippon Sumitomo Pharma Co., Ltd.
InventorsYoko Takahashi, Ryu Nagata, Kantaro Ushiroda
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Abstract
A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.
Claims28
A compound of the formula (1):
- wherein Ring Z is an optionally substituted heteroaryl;
- W4 is a single bond, —NR10—NR10—W6— (in which R10 is a hydrogen atom, or an optionally substituted lower alkyl, and W6 is a lower alkylene), a lower alkylene, or a lower alkenylene;
- Ar2 is an optionally substituted aryl or an optionally substituted heteroaryl,
- W3 is a single bond, a lower alkylene, a lower alkenylene, or —Y1—W5— (in which Y1 is an oxygen atom, a sulfur atom, —S(O)— or —S(O)2—, and W5 is a lower alkylene or a lower alkenylene);
- Ar1 is an optionally substituted arylene or an optionally substituted heteroarylene;
- W1 and W2 are independently an optionally substituted lower alkylene or an optionally substituted lower alkenylene;
- R1 is a carboxyl group, an alkoxycarbonyl group, an optionally substituted carbamoyl group, an optionally substituted cyclic aminocarbonyl group, an optionally substituted alkylsulfonylcarbamoyl group, an optionally substituted arylsulfonylcarbamoyl group, or a tetrazolyl group,
- or a prodrug thereof, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.