Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors

A compound having the formula (I)

• its enantiomers, diastereomers, and pharmaceutically-acceptable salts, prodrugs, and solvates thereof, wherein:
• J is nitrogen or —CR8;
• K is nitrogen or carbon, wherein when K is nitrogen, the bond between K and carbon atom C* is a single bond, and when K is carbon, the bond between K and carbon atom C* is a double bond;
• Z is selected from —NHR11, —C(═O)NR11R12, —NR11C(O)2R12, —NR11C(═O)R13, —NR11C(═O)NR12R13, —NR11SO2R14, —SO2NR12, —C(═O)R12, —OC(═O)R15, —C(═O)NR11C(═O)R13, —C(═O)NR11C(═O)NR12R13, and optionally-substituted heteroaryl;
• R5 is hydrogen or C1-4alkyl;
• R6a and R6b are independently selected from hydrogen, C1-4alkyl, hydroxy, methoxy, halogen, cyano, amino, —NH(C1-4alkyl), —N(C1-4alkyl)2, —CF3, —OCF3, and C1-4alkyl substituted with one or two of hydroxy, methoxy, halogen, cyano, amino, —NH(C1-4alkyl), —N(C1-4alkyl)2-CF3, and/or —OCF3;
• R and R8 are independently selected from hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, halogen, cyano, amino, alkylamino, haloalkoxy, cycloalkyl, aryl, heterocyclo, and heteroaryl;
• R1 and R2 are taken together to form a ring fused to ring D via bond K*, wherein (a) when K is carbon, R1 and R2 (considered together with K, the C* atom, and the bond joining K and C*), form a fused ring selected from one of:
• wherein M is —N(R7)— or sulfur;
• and (b) when K is nitrogen, R1 and R2 (considered together with K, the C* atom, and the bond joining K and C*), form a fused ring selected from one of:
• provided, however, that when J and K are both nitrogen, R1 and R2 do not form ring (T1);
• and provided further that when J is N, K is carbon, and R1 and R2 form ring (S1), then Z is —C(═O)NR11R12;
• X is selected from —O—, —OC(═O)—, —S—, —S(═O)—, —SO2—, —C(═O)—, —CO2—, —NR15—, —NR15C(═O)—, —NR15C(═O)NR15a—, —NR15CO2—, —NR15SO2—, —NR15SO2NR15a—, —SO2NR15—, —C(═O)NR15—, halogen, nitro, and cyano, or X is absent;
• X1 is selected from —C(═O)—, —CO2—, —NR15—, —NR15C(═O)—, —NR15C(═O)NR15a—, —NR15CO2—, —NR15 SO2—, —NR15 SO2NR15a—, —SO2NR15—, —C(═O)NR15—, and nitro, or X1 is absent;
• R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, NH2, or NH(CH3);
• R4 is selected from:
• (a) hydrogen, provided that R4 is not hydrogen if either X is —S(═O)—, —SO2—, —NR15CO2—, or —NR15SO2—, or X1 is —NR15CO2—, or —NR15SO2—;
• (b) alkyl, alkenyl, and alkynyl optionally independently substituted with keto and/or one to four R17;
• (c) aryl and heteroaryl either of which may be optionally independently substituted with one to three R16;
• and
• (d) heterocyclo and cycloalkyl either of which may be optionally independently substituted with keto and/or one to three R16;
• or
• (e) R4 is absent if X is halogen, nitro, or cyano or if X1 is nitro;
• R7 is selected from alkyl, substituted alkyl, aryl, and heteroaryl;
• R9 is selected from hydrogen, alkyl, substituted alkyl, halogen, cyano, aryl, heteroaryl,
• —SR10, and —S(O)2R10, wherein R10 is alkyl or substituted alkyl;
• R11 is hydrogen, alkyl, or substituted alkyl;
• R12, R13 and R14 are independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, hydroxy, alkoxy, aryl, cycloalkyl, heteroaryl, and heterocyclo, except R14 is not hydrogen;
• R15 and R15a are independently selected from hydrogen, alkyl, substituted alkyl, aryl, cycloalkyl, heterocyclo, and heteroaryl;
• R16 is selected from alkyl, R17, and C1-4alkyl substituted with keto (═O) and/or one to three R17;
• R17 is selected from
• (a) halogen, haloalkyl, haloalkoxy, nitro, cyano, —SR23, —OR23, —NR23R24, —NR23SO2R25, —SO2R25, —SO2NR23R24, —CO2R23, —C(═O)R23, —C(═O)NR23R24, —OC(═O)R23, —OC(═O)NR23R24, —NR23C(═O)R24, —NR23CO2R24;
• (b) aryl or heteroaryl either of which may be optionally substituted with one to three R26;
• or
• (c) cycloalkyl or heterocyclo optionally substituted with keto(═O) and/or one to three R26;
• R23, R24 and R25 are each independently selected from hydrogen, alkyl, alkenyl, substituted alkyl, substituted alkenyl, aryl, cycloalkyl, heteroaryl, and heterocyclo, except R25 is not hydrogen;
• R26 is at each occurrence independently selected from C1-6alkyl, C2-6alkenyl, halogen, haloalkyl, haloalkoxy, cyano, nitro, amino, C1-4alkylamino, aminoC1-4alkyl, hydroxy, hydroxyC1-4alkyl, C1-4alkoxy, C1-4alkylthio, phenyl, five to six membered heterocyclo, (phenyl)C1-4alkyl, phenoxy, and (phenyl)C1-4alkoxy;
• and
• p is 0, 1, 2 or 3.