Peptide Deformylase Inhibitors

A compound according to Formula (1):

• wherein:
• Y represents —C(O)— or a covalent bond;
• R represents a substituted arylene, a substituted heteroarylene or a covalent bond;
• Z represents —CH2—, —NR3—, —O—, —C(O)NR3—, —NR3C(O)— or —CH═CH— when R is a substituted arylene or a substituted heteroarylene, and represents —CH2— or —CH═CH— when R is a covalent bond;
• R3 is hydrogen, C1-3 substituted alkyl, and (CH2)0-2—C3-6 substituted carbocycle;
• R1 is selected from the group consisting of:
• hydrogen, C1-3 substituted alkyl, C2-3 substituted alkenyl, C2-3 substituted alkynyl, and (CH2)0-2—C3-6 substituted carbocycle;
• m is equal to 0 when Z=—NR3— or —CH2—;
• or m is equal to 0 or 1 when Z=—O—, —C(O)NR3— or —NR3C(O)—;
• or m is is an integer between 0 and 6 when Z=—CH═CH—;
• n is an integer equal to or greater than 2, appropriately chosen so that the number of atoms in the macrocyclic ring ranges from 13 to 16;
• or a salt, solvate, or physiologically functional derivative thereof.