Neurogenesis by modulating angiotensin
AssigneeBrainCells, Inc.
InventorsCarolee Barlow, Todd A. Carter, Kai Treuner, Kym I. Lorrain
Life of this patent
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Abstract
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes compositions and methods based on modulation angiotensin activity to stimulate or activate the formation of new nerve cells.
Claims40
A method of treating a nervous system disorder related to cellular degeneration, a psychiatric condition, cellular trauma and/or injury, or another neurologically related condition in a subject or patient, said method comprising administering a modulator of angiotensin activity to produce an improvement in said disorder in said subject or patient.
A method of preparing cells or tissue for transplantation to a subject or patient, said method comprising contacting said cell or tissue with a modulator of angiotensin activity to stimulate or increase neurogenesis in said cell or tissue.
A method of stimulating or increasing neurogenesis in a cell or tissue, said method comprising contacting said cell or tissue with a modulator of angiotensin activity, and an amount of a neurogenic agent, wherein the combination of the modulator and neurogenic agent is effective to produce neurogenesis in said cell or tissue.
25-27. (canceled)
29-30. (canceled)
(canceled)
A composition comprising candesartan, captopril or telmisartan in combination with baclofen, or donepezil.
A composition comprising ibudilast, theophylline, enoximone, rolipram, or vardenafil in combination with aliskerin.
Dependencies are inferred from the claim text.