Methods of treating skin disorders with caffeic acid analogs
OwnerCharles Conrad, Waldemar Priebe +2inventors
InventorsCHARLES CONRAD, Waldemar Priebe, Walter V. Klemp, Robert A. Conrad
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Abstract
Methods of treating skin diseases such as plaque psoriasis and inverse psoriasis include topical application of one or a combination of caffeic acid phenethyl ester, caffeic acid benzyl ester, and analogs thereof as an active agent. A pharmaceutical composition containing the active agent may further include a cell differentiating agent such as a retinoid, and/or vitamin D or analogs thereof. The method enables treatment of a lesion with active agent dosages of ten percent by weight, for example.
Claims20
A method of treating plaque psoriasis or inverse psoriasis, comprising:
- applying a topical pharmaceutical composition to a lesion, wherein the composition comprises one of caffeic acid phenethyl ester (CAPE), caffeic acid benzyl ester (CABE), an analog of CAPE, an analog of CABE, and a pharmaceutically acceptable salt thereof.
A composition for topical application to psoriatic lesions, comprising:
- a carrier suitable for topical administration;
- and
- one of caffeic acid phenethyl ester (CAPE), caffeic acid benzyl ester (CABE), an analog of CAPE, an analog of CABE, and a pharmaceutically acceptable salt thereof.
A method of treating plaque psoriasis or inverse psoriasis, comprising:
- inhibiting a Signal Transducers and Activators of Transcription 3 (STAT3) signaling pathway by applying a topical pharmaceutical composition to a lesion, wherein the composition comprises at least one of caffeic acid phenethyl ester (CAPE), caffeic acid benzyl ester (CABE), an analog of CAPE, an analog of CABE, and a pharmaceutically acceptable salt thereof in an effective amount to achieve inactivation of the STAT3 pathway.
Dependencies are inferred from the claim text.