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US 2008/0167271 A1Published application
Pharmaceutical compositions comprising a bisphosphonate compound
AssigneeBesins Healthcare SA
InventorValerie MASINI-ETEVE
Life of this patent
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Abstract
The present invention relates to pharmaceutical compositions comprising a bisphosphonate compound.
Claims16
A pharmaceutical composition comprising:
- (i) a therapeutically effective amount of at least one bisphosphonate,
- (ii) a non-irritating amount of at least one moisturizer,
- (iii) at most 0-12% of a short-chain aliphatic alcohol selected from the group consisting of ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, isobutanol and mixtures thereof,
- (iv) at least one gelling agent,
- (v) optionally, at least one surfactant, and
- (vi) water,
- wherein said composition
- is a stable, macroscopically homogeneous mixture,
- has a pH of between 4.0 and 8.5, and
- is non-occlusive and non film-forming.
7 more elements
A method of administering a therapeutically effective amount of at least one bisphosphonate to a patient in need thereof, comprising topically administering to a surface of skin of the patient a pharmaceutical composition comprising:
- (i) a therapeutically effective amount of at least one bisphosphonate,
- (ii) a non-irritating amount of at least one moisturizer,
- (iii) at most 0-12% of a short-chain aliphatic alcohol selected from the group consisting of ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, isobutanol and mixtures thereof,
- (iv) at least one gelling agent,
- (v) optionally, at least one surfactant, and
- (vi) water,
- wherein said composition
- is a stable, macroscopically homogeneous mixture,
- has a pH of between 4.0 and 8.5, and
- is non-occlusive and non film-forming.
7 more elements
A method for treating a bone-related disorder, comprising topically administering to a surface of skin of a patient in need thereof, a therapeutically effective amount of a pharmaceutical composition comprising:
- (i) a therapeutically effective amount of at least one bisphosphonate,
- (ii) a non-irritating amount of at least one moisturizer,
- (iii) at most 0-12% of a short-chain aliphatic alcohol selected from the group consisting of ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, isobutanol and mixtures thereof,
- (iv) at least one gelling agent,
- (v) optionally, at least one surfactant, and
- (vi) water,
- wherein said composition
- is a stable, macroscopically homogeneous mixture,
- has a pH of between 4.0 and 8.5, and
- is non-occlusive and non film-forming.
7 more elements
Dependencies are inferred from the claim text.