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US 2008/0167265 A1Published application
Modulation of fr-alpha expression
AssigneeIsis Pharmaceuticals, Inc.
InventorSusan M. Freier
Life of this patent
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Abstract
Disclosed herein are compounds, compositions and methods for modulating the expression of FR-alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
Claims25
An oligomeric compound of 12 to 50 nucleobases targeted to a nucleic acid molecule encoding FR-alpha, wherein said oligomeric compound inhibits the expression of FR-alpha.
A method of screening for a modulator of FR-alpha, the method comprising the steps of:
- contacting a target segment of a nucleic acid molecule encoding FR-alpha with one or more candidate modulators to FR-alpha, and
- identifying one or more modulators of FR-alpha expression which modulate the expression of FR-alpha.
Dependencies are inferred from the claim text.