Materials and methods to inhibit hodgkin and reed sternberg cell growth
AssigneeAmgen Inc.
InventorsTak W. Mak, Ursula Kapp
Life of this patent
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Abstract
Materials and methods are disclosed for modulating proliferation of cell types associated with Hodgkin's disease through inhibition of IL-13 and components in IL-13 associated signal transduction pathways. Methods to identify inhibitors, compositions comprising the inhibitors, and methods using the inhibitors to treat Hodgkin's disease are also disclosed.
Claims18
-6. (canceled)
A method for inhibiting IL-13 dependent proliferation of Hodgkin and Reed Sternberg (H/RS) cell types comprising the step of contacting the H/RS cells with a compound that inhibits expression of IL-13.
A method for inhibiting IL-13 dependent proliferation of Hodgkin and Reed Sternberg (H/RS) cell types comprising the step of contacting the H/RS cells with a compound that inhibits expression of IL-13 receptor.
13-20. (canceled)
A method to identify a compound that inhibits IL-13 dependent proliferation of Hodgkin and Reed Sternberg (H/RS) cell types comprising the steps of:
- a) growing H/RS cell types
- b) measuring IL-13 expression
- c) incubating the cells with a candidate inhibitor compound
- d) measuring IL-13 expression with the candidate compound
- e) identifying the candidate compound as an inhibitor when lower levels of IL-13 expression are measured with the candidate compound than in an absence of the candidate compound.
24-26. (canceled)
A method for treating Hodgkin's Disease comprising the steps of administering to an individual in need thereof a therapeutically effective amount of a compound that inhibits IL-13 expression.
30-32. (canceled)
A method for treating Hodgkin's Disease comprising the step of administering to an individual in need thereof a therapeutically effective amount of a compound that inhibits IL-13 receptor expression.
34-39. (canceled)
Dependencies are inferred from the claim text.