Methods and compositions for diagnosing and treating prostate cancer
AssigneeThe Regents of the University of Michigan
InventorsKathleen A. Cooney, Julie A. Douglas, Albert M. Levin
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Abstract
The present invention relates to compositions and methods for cancer research, diagnosis, and treatment, including but not limited to, cancer markers. In particular, the present invention relates to BRCA1 markers for prostate cancer.
Claims14
A method of diagnosing prostate cancer, comprising
- a) detecting the presence or absence of a BRCA1 single nucleotide polymorphism, wherein said polymorphism is rs1799950 in a sample from a subject;
- and
- b) determining the presence or absence of prostate cancer in said sample based on said presence or absence of said BRCA1 single nucleotide polymorphism.
A method of diagnosing prostate cancer, comprising
- a) detecting the presence or absence of a BRCA1 single nucleotide polymorphism, wherein said polymorphism is rs3737559 in a sample from a subject;
- and
- b) determining the presence or absence of prostate cancer in said sample based on said presence or absence of said BRCA1 single nucleotide polymorphism.
A method of diagnosing prostate cancer, comprising
- a) detecting the presence or absence of a BRCA1 single nucleotide polymorphism, wherein said polymorphism is rs799923 in a sample from a subject;
- and
- b) determining the presence or absence of prostate cancer in said sample based on said presence or absence of said BRCA1 single nucleotide polymorphism.
A kit comprising reagents for detecting the presence or absence of a BRCA1 single nucleotide polymorphism selected from the group consisting of rs1799950, rs3737559, and rs799923.
A method, comprising:
- a) contacting a prostate cancer cell expressing a BRCA1 gene comprising a BRCA1 single nucleotide polymorphism selected from the group consisting of rs1799950, rs3737559, and rs799923 with a test compound;
- b) identifying a test compound that impairs proliferation of or kills said cell.
Dependencies are inferred from the claim text.